Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel “unnatural” natural products

The structures of complex polyketide natural products, such as erythromycin, are programmed by multifunctional polyketide synthases (PKSs) that contain modular arrangements of functional domains. The colinearity between the activities of modular PKS domains and structure of the polyketide product po...

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Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	McDaniel, Robert, Thamchaipenet, Arinthip, Gustafsson, Claes, Fu, Hong, Betlach, Melanie, Betlach, Mary, Ashley, Gary
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 1999
Предметы:	Biological Sciences
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26699/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10051557/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.5.1846
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