Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel “unnatural” natural products

The structures of complex polyketide natural products, such as erythromycin, are programmed by multifunctional polyketide synthases (PKSs) that contain modular arrangements of functional domains. The colinearity between the activities of modular PKS domains and structure of the polyketide product po...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	McDaniel, Robert, Thamchaipenet, Arinthip, Gustafsson, Claes, Fu, Hong, Betlach, Melanie, Betlach, Mary, Ashley, Gary
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26699/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10051557/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.5.1846
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