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High-level Expression of Glycoprotein D by a Dominant-negative HSV-1 Virus Augments Its Efficacy as a Vaccine Against HSV-1 Infection

Using the T-REx™ (Invitrogen, CA) gene switch technology, we previously generated a dominant-negative HSV-1 recombinant, CJ83193, capable of inhibiting its own replication as well as that of wild-type HSV-1 and HSV-2. It has been further demonstrated that CJ83193 is an effective vaccine against HSV-...

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Autors principals: Lu, Zheming, Brans, Richard, Akhrameyeva, Natali V., Murakami, Nao, Xu, Ximing, Yao, Feng
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669847/
https://ncbi.nlm.nih.gov/pubmed/19005489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2008.349
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