An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRB1 gene

BACKGROUND: Multiple sclerosis (MS) is a complex trait in which genes in the MHC class II region exert the single strongest effect on genetic susceptibility. The principal MHC class II haplotype that increases MS risk in individuals of Northern European descent are those that bear HLA-DRB1*15. Howev...

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Detalhes bibliográficos
Main Authors: Ramagopalan, Sreeram V, McMahon, Roisin, Dyment, David A, Sadovnick, A Dessa, Ebers, George C, Wittkowski, Knut M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669470/
https://ncbi.nlm.nih.gov/pubmed/19193207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-10-10
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