An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRB1 gene

BACKGROUND: Multiple sclerosis (MS) is a complex trait in which genes in the MHC class II region exert the single strongest effect on genetic susceptibility. The principal MHC class II haplotype that increases MS risk in individuals of Northern European descent are those that bear HLA-DRB1*15. Howev...

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Bibliografiske detaljer
Main Authors: Ramagopalan, Sreeram V, McMahon, Roisin, Dyment, David A, Sadovnick, A Dessa, Ebers, George C, Wittkowski, Knut M
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669470/
https://ncbi.nlm.nih.gov/pubmed/19193207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-10-10
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