Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility

Multiple sclerosis (MS), a common central nervous system inflammatory disease, has a major heritable component. Susceptibility is associated with the MHC class II region, especially HLA-DRB5*0101–HLA-DRB1*1501–HLA-DQA1*0102–HLA-DQB1*0602 haplotypes(hereafter DR2), which dominate genetic contribution...

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Main Authors: Lincoln, Matthew R., Ramagopalan, Sreeram V., Chao, Michael J., Herrera, Blanca M., DeLuca, Gabriele C., Orton, Sarah-Michelle, Dyment, David A., Sadovnick, A Dessa, Ebers, George C.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2678609/
https://ncbi.nlm.nih.gov/pubmed/19380721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812664106
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