Loss of LR11/SORLA Enhances Early Pathology in a Mouse Model of Amyloidosis: Evidence for a Proximal Role in Alzheimer's Disease

Alzheimer's disease (AD) is the most prevalent form of dementia, resulting in progressive neuronal death and debilitating damage to brain loci that mediate memory and higher cognitive function. While pathogenic genetic mutations have been implicated in ∼2% of AD cases, the proximal events that...

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Detalhes bibliográficos
Principais autores: Dodson, Sara E., Andersen, Olav M., Karmali, Vinit, Fritz, Jason J., Cheng, Dongmei, Peng, Junmin, Levey, Allan I., Willnow, Thomas E., Lah, James J.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669320/
https://ncbi.nlm.nih.gov/pubmed/19036982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4582-08.2008
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