Tgfbr1 haploinsufficiency is a potent modifier of colorectal cancer development

TGF-β signaling is frequently altered in colorectal cancer. Using a novel model of mice heterozygous for a targeted null mutation of Tgfbr1 crossed with Apc(Min/+) mice, we show that Apc(Min/+);Tgfbr1(+/−) mice develop twice as many intestinal tumors as Apc(Min/+) ;Tgfbr1(+/+) mice as well as adenoc...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Zeng, Qinghua, Phukan, Sharbani, Xu, Yanfei, Sadim, Maureen, Rosman, Diana S., Pennison, Michael, Liao, Jie, Zhang, Meng, Yang, Guang-Yu, Huang, Chiang-Ching, Valle, Laura, Di Cristofano, Antonio, de la Chapelle, Albert, Pasche, Boris
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668823/
https://ncbi.nlm.nih.gov/pubmed/19147584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-3980
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados