Somatic acquisition of TGFBR1*6A by epithelial and stromal cells during head and neck and colon cancer development

TGFBR1*6A is a common hypomorphic variant of the type I transforming growth factor (TGF)-β receptor (TGFBR1), which transduces TGF-β growth inhibitory signals less effectively than TGFBR1. Recent studies suggest that TGFBR1*6A confers a selective growth advantage to both normal appearing and cancero...

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Hlavní autoři: Bian, Yansong, Knobloch, Thomas J., Sadim, Maureen, Kaklamani, Virginia, Raji, Adekunle, Yang, Guang-Yu, Weghorst, Christopher M., Pasche, Boris
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637554/
https://ncbi.nlm.nih.gov/pubmed/17890272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddm274
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