Microsatellite Instability Predicts Improved Response to Adjuvant Therapy With Irinotecan, Fluorouracil, and Leucovorin in Stage III Colon Cancer: Cancer and Leukemia Group B Protocol 89803

PURPOSE: Colon cancers exhibiting DNA mismatch repair (MMR) defects demonstrate distinct clinical and pathologic features, including better prognosis and reduced response to fluorouracil (FU) –based chemotherapy. This prospective study investigated adjuvant chemotherapy containing FU and irinotecan...

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Detalhes bibliográficos
Main Authors: Bertagnolli, Monica M., Niedzwiecki, Donna, Compton, Carolyn C., Hahn, Hejin P., Hall, Margaret, Damas, Beatrice, Jewell, Scott D., Mayer, Robert J., Goldberg, Richard M., Saltz, Leonard B., Warren, Robert S., Redston, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2009
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668707/
https://ncbi.nlm.nih.gov/pubmed/19273709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2008.18.2071
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