A Chimeric A2 Strain of Respiratory Syncytial Virus (RSV) with the Fusion Protein of RSV Strain Line 19 Exhibits Enhanced Viral Load, Mucus, and Airway Dysfunction

Respiratory syncytial virus (RSV) is the leading cause of respiratory failure and viral death in infants. Abundant airway mucus contributes to airway obstruction in RSV disease. Interleukin-13 (IL-13) is a mediator of pulmonary mucus secretion. It has been shown that infection of BALB/c mice with th...

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Detalhes bibliográficos
Main Authors: Moore, Martin L., Chi, Michael H., Luongo, Cindy, Lukacs, Nicholas W., Polosukhin, Vasiliy V., Huckabee, Matthew M., Newcomb, Dawn C., Buchholz, Ursula J., Crowe, James E., Goleniewska, Kasia, Williams, John V., Collins, Peter L., Peebles, R. Stokes
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668460/
https://ncbi.nlm.nih.gov/pubmed/19211758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01853-08
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