A Chimeric A2 Strain of Respiratory Syncytial Virus (RSV) with the Fusion Protein of RSV Strain Line 19 Exhibits Enhanced Viral Load, Mucus, and Airway Dysfunction

Respiratory syncytial virus (RSV) is the leading cause of respiratory failure and viral death in infants. Abundant airway mucus contributes to airway obstruction in RSV disease. Interleukin-13 (IL-13) is a mediator of pulmonary mucus secretion. It has been shown that infection of BALB/c mice with th...

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Bibliografiske detaljer
Main Authors: Moore, Martin L., Chi, Michael H., Luongo, Cindy, Lukacs, Nicholas W., Polosukhin, Vasiliy V., Huckabee, Matthew M., Newcomb, Dawn C., Buchholz, Ursula J., Crowe, James E., Goleniewska, Kasia, Williams, John V., Collins, Peter L., Peebles, R. Stokes
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668460/
https://ncbi.nlm.nih.gov/pubmed/19211758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01853-08
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