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Contribution of IRF-3 Mediated IFNβ Production to DNA Vaccine Dependent Cellular Immune Responses

The mechanism(s) by which DNA vaccines activate Ag-specific cellular immune responses is incompletely understood. Current findings indicate that IRF-3 plays an important role in this process. The IRF-3 dependent signaling pathway is triggered by the presence of intracytoplasmic DNA, and culminates i...

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Autors principals: Shirota, Hidekazu, Petrenko, Lev, Hattori, Toshio, Klinman, Dennis M.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667800/
https://ncbi.nlm.nih.gov/pubmed/19356618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2009.01.134
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