Sumoylation of the Transcription Factor NFATc1 Leads to Its Subnuclear Relocalization and Interleukin-2 Repression by Histone Deacetylase

The family of NFAT (nuclear factor of activated T-cells) transcription factors plays an important role in cytokine gene regulation. In peripheral T-cells NFATc1 and -c2 are predominantly expressed. Because of different promoter and poly(A) site usage as well as alternative splicing events, NFATc1 is...

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Bibliographic Details
Main Authors: Nayak, Arnab, Glöckner-Pagel, Judith, Vaeth, Martin, Schumann, Julia E., Buttmann, Mathias, Bopp, Tobias, Schmitt, Edgar, Serfling, Edgar, Berberich-Siebelt, Friederike
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667779/
https://ncbi.nlm.nih.gov/pubmed/19218564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M900465200
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