Unidirectional Binding of Clostridial Collagenase to Triple Helical Substrates

Histotoxic clostridia produce collagenases responsible for extensive tissue destruction in gas gangrene. The C-terminal collagen-binding domain (CBD) of these enzymes is the minimal segment required to bind to collagen fibril. Collagen binding efficiency of CBD is more pronounced in the presence of...

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Bibliografiske detaljer
Main Authors: Philominathan, Sagaya Theresa Leena, Koide, Takaki, Hamada, Kentaro, Yasui, Hiroyuki, Seifert, Soenke, Matsushita, Osamu, Sakon, Joshua
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667773/
https://ncbi.nlm.nih.gov/pubmed/19208618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807684200
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