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Bacterial collagen-binding domain targets undertwisted regions of collagen

Clostridium histolyticum collagenase causes extensive degradation of collagen in connective tissue that results in gas gangrene. The C-terminal collagen-binding domain (CBD) of these enzymes is the minimal segment required to bind to a collagen fibril. CBD binds unidirectionally to the undertwisted...

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Detalhes bibliográficos
Main Authors: Philominathan, Sagaya Theresa Leena, Koide, Takaki, Matsushita, Osamu, Sakon, Joshua
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526996/
https://ncbi.nlm.nih.gov/pubmed/22898990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2145
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