Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells

PCSK9 is a secreted protein that degrades low density lipoprotein receptors (LDLRs) in liver by binding to the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR. It is not known whether PCSK9 causes degradation of LDLRs within the secretory pathway or following secretion and reuptake...

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Hlavní autoři: McNutt, Markey C., Kwon, Hyock Joo, Chen, Chiyuan, Chen, Justin R., Horton, Jay D., Lagace, Thomas A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667743/
https://ncbi.nlm.nih.gov/pubmed/19224862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808802200
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