Structural and Functional Analysis of a C3b-specific Antibody That Selectively Inhibits the Alternative Pathway of Complement

Amplification of the complement cascade through the alternative pathway can lead to excessive inflammation. Targeting C3b, a component central to the alternative pathway of complement, provides a powerful approach to inhibit complement-mediated immune responses and tissue injury. In the present stud...

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Bibliographic Details
Main Authors: Katschke, Kenneth J., Stawicki, Scott, Yin, Jianping, Steffek, Micah, Xi, Hongkang, Sturgeon, Lizette, Hass, Philip E., Loyet, Kelly M., DeForge, Laura, Wu, Yan, van Lookeren Campagne, Menno, Wiesmann, Christian
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667734/
https://ncbi.nlm.nih.gov/pubmed/19196712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809106200
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