Mechanism of Dihydrouridine Synthase 2 from Yeast and the Importance of Modifications for Efficient tRNA Reduction

Dihydrouridine synthases (DUSs) are flavin-dependent enzymes that catalyze site-specific reduction of uracils in tRNAs. The mechanism of DUS 2 from Saccharomyces cerevisiae was studied. Previously published turnover rates for this DUS were very low. Our studies show that the catalytic cycle consists...

Full description

Saved in:
Bibliographic Details
Main Authors: Rider, Lance W., Ottosen, Mette B., Gattis, Samuel G., Palfey, Bruce A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Enzyme Catalysis and Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667719/
https://ncbi.nlm.nih.gov/pubmed/19139092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806137200
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items