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Major reorientation of tRNA substrates defines specificity of dihydrouridine synthases
The reduction of specific uridines to dihydrouridine is one of the most common modifications in tRNA. Increased levels of the dihydrouridine modification are associated with cancer. Dihydrouridine synthases (Dus) from different subfamilies selectively reduce distinct uridines, located at spatially u...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4434734/ https://ncbi.nlm.nih.gov/pubmed/25902496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500161112 |
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