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Major reorientation of tRNA substrates defines specificity of dihydrouridine synthases

The reduction of specific uridines to dihydrouridine is one of the most common modifications in tRNA. Increased levels of the dihydrouridine modification are associated with cancer. Dihydrouridine synthases (Dus) from different subfamilies selectively reduce distinct uridines, located at spatially u...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Byrne, Robert T., Jenkins, Huw T., Peters, Daniel T., Whelan, Fiona, Stowell, James, Aziz, Naveed, Kasatsky, Pavel, Rodnina, Marina V., Koonin, Eugene V., Konevega, Andrey L., Antson, Alfred A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2015
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4434734/
https://ncbi.nlm.nih.gov/pubmed/25902496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500161112
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