The CREB Coactivator TORC1 is Required for Energy Balance and Fertility

Obesity is a major risk factor in the development of insulin resistance and Type 2 diabetes. Under lean conditions, the adipocyte-derived hormone leptin maintains energy balance by acting on hypothalamic leptin receptors (LRbs) that trigger activation of the JAK2/STAT3 pathway 1–4. Although disrupti...

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Autores principales: Altarejos, Judith Y., Goebel, Naomi, Conkright, Michael D., Inoue, Hiroshi, Xie, Xianjin, Arias, Carlos M., Sawchenko, Paul E., Montminy, Marc
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667698/
https://ncbi.nlm.nih.gov/pubmed/18758446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.1866
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