Phenotypes and gene expression profiles of Saccharopolyspora erythraea rifampicin-resistant (rif) mutants affected in erythromycin production

BACKGROUND: There is evidence from previous works that bacterial secondary metabolism may be stimulated by genetic manipulation of RNA polymerase (RNAP). In this study we have used rifampicin selection as a strategy to genetically improve the erythromycin producer Saccharopolyspora erythraea. RESULT...

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Autori principali: Carata, Elisabetta, Peano, Clelia, Tredici, Salvatore M, Ferrari, Francesco, Talà, Adelfia, Corti, Giorgio, Bicciato, Silvio, De Bellis, Gianluca, Alifano, Pietro
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2009
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667423/
https://ncbi.nlm.nih.gov/pubmed/19331655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2859-8-18
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