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HMGB1/2 can target DNA for illegitimate cleavage by the RAG1/2 complex

BACKGROUND: V(D)J recombination is initiated in antigen receptor loci by the pairwise cleavage of recombination signal sequences (RSSs) by the RAG1 and RAG2 proteins via a nick-hairpin mechanism. The RSS contains highly conserved heptamer (consensus: 5'-CACAGTG) and nonamer (consensus: 5'-...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Zhang, Ming, Swanson, Patrick C
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2009
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666730/
https://ncbi.nlm.nih.gov/pubmed/19317908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-10-24
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