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HMGB1/2 can target DNA for illegitimate cleavage by the RAG1/2 complex
BACKGROUND: V(D)J recombination is initiated in antigen receptor loci by the pairwise cleavage of recombination signal sequences (RSSs) by the RAG1 and RAG2 proteins via a nick-hairpin mechanism. The RSS contains highly conserved heptamer (consensus: 5'-CACAGTG) and nonamer (consensus: 5'-...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2666730/ https://ncbi.nlm.nih.gov/pubmed/19317908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-10-24 |
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