Molecular Mechanism Underlying RAG1/RAG2 Synaptic Complex Formation

Two lymphoid cell-specific proteins, RAG1 and RAG2 (RAG), initiate V(D)J recombination by assembling a synaptic complex with recombination signal sequences (RSSs) abutting two different antigen receptor gene coding segments, and then introducing a DNA double strand break at the end of each RSS. Desp...

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Hlavní autoři: Shlyakhtenko, Luda S., Gilmore, Jamie, Kriatchko, Aleksei N., Kumar, Sushil, Swanson, Patrick C., Lyubchenko, Yuri L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742861/
https://ncbi.nlm.nih.gov/pubmed/19502597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.028977
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