Mutant Presenilin 1 Increases the Expression and Activity of BACE1

Mutations of the presenilin 1 (PS1) gene are the most common cause of early onset familial Alzheimer disease (FAD). PS1 mutations alter the activity of the γ-secretase on the β-amyloid precursor protein (APP), leading to selective overproduction of β-amyloid (Aβ) 42 peptides, the species that forms...

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Detalhes bibliográficos
Main Authors: Giliberto, Luca, Borghi, Roberta, Piccini, Alessandra, Mangerini, Rosa, Sorbi, Sandro, Cirmena, Gabriella, Garuti, Anna, Ghetti, Bernardino, Tagliavini, Fabrizio, Mughal, Mohamed R., Mattson, Mark P., Zhu, Xiongwei, Wang, Xinglong, Guglielmotto, Michela, Tamagno, Elena, Tabaton, Massimo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666551/
https://ncbi.nlm.nih.gov/pubmed/19196715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805685200
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