Oxidative stress activates a positive feedback between the γ- and β-secretase cleavages of the β-amyloid precursor protein

Sequential cleavages of the β-amyloid precursor protein cleaving enzyme 1 (BACE1) by β-secretase and γ-secretase generate the amyloid β-peptides, believed to be responsible of synaptic dysfunction and neuronal cell death in Alzheimer's disease (AD). Levels of BACE1 are increased in vulnerable r...

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Detalhes bibliográficos
Main Authors: Tamagno, Elena, Guglielmotto, Michela, Aragno, Manuela, Borghi, Roberta, Autelli, Riccardo, Giliberto, Luca, Muraca, Giuseppe, Danni, Oliviero, Zhu, Xiongwei, Smith, Mark A., Perry, George, Jo, Dong-Gyu, Mattson, Mark P., Tabaton, Massimo
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2220052/
https://ncbi.nlm.nih.gov/pubmed/18005001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2007.05072.x
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