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Oxidative stress activates a positive feedback between the γ- and β-secretase cleavages of the β-amyloid precursor protein
Sequential cleavages of the β-amyloid precursor protein cleaving enzyme 1 (BACE1) by β-secretase and γ-secretase generate the amyloid β-peptides, believed to be responsible of synaptic dysfunction and neuronal cell death in Alzheimer's disease (AD). Levels of BACE1 are increased in vulnerable r...
Kaydedildi:
| Asıl Yazarlar: | , , , , , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2007
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2220052/ https://ncbi.nlm.nih.gov/pubmed/18005001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2007.05072.x |
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