Oxidative stress activates a positive feedback between the γ- and β-secretase cleavages of the β-amyloid precursor protein

Sequential cleavages of the β-amyloid precursor protein cleaving enzyme 1 (BACE1) by β-secretase and γ-secretase generate the amyloid β-peptides, believed to be responsible of synaptic dysfunction and neuronal cell death in Alzheimer's disease (AD). Levels of BACE1 are increased in vulnerable r...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Tamagno, Elena, Guglielmotto, Michela, Aragno, Manuela, Borghi, Roberta, Autelli, Riccardo, Giliberto, Luca, Muraca, Giuseppe, Danni, Oliviero, Zhu, Xiongwei, Smith, Mark A., Perry, George, Jo, Dong-Gyu, Mattson, Mark P., Tabaton, Massimo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2007
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2220052/
https://ncbi.nlm.nih.gov/pubmed/18005001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2007.05072.x
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller