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A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal
We performed a genome-wide siRNA screen in mouse embryonic stem (ES) cells to identify genes essential for self-renewal, and found 148 genes whose down-regulation caused differentiation. Many of the identified genes function in gene regulation and/or development, and are highly expressed in ES cells...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2666338/ https://ncbi.nlm.nih.gov/pubmed/19339689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1769609 |
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