Drosophila Genome-Wide RNAi Screen Identifies Multiple Regulators of HIF–Dependent Transcription in Hypoxia

Hypoxia-inducible factors (HIFs) are a family of evolutionary conserved alpha-beta heterodimeric transcription factors that induce a wide range of genes in response to low oxygen tension. Molecular mechanisms that mediate oxygen-dependent HIF regulation operate at the level of the alpha subunit, con...

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Detalhes bibliográficos
Main Authors: Dekanty, Andrés, Romero, Nuria M., Bertolin, Agustina P., Thomas, María G., Leishman, Claudia C., Perez-Perri, Joel I., Boccaccio, Graciela L., Wappner, Pablo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891703/
https://ncbi.nlm.nih.gov/pubmed/20585616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000994
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