IRAK-4/MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans

Most autoreactive B cells are normally counterselected during early B cell development. To determine whether Toll-like receptors (TLRs) regulate the removal of autoreactive B lymphocytes, we tested the reactivity of recombinant antibodies from single B cells isolated from patients deficient for IRAK...

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Hlavní autoři: Isnardi, Isabelle, Ng, Yen-Shing, Srdanovic, Iva, Motaghedi, Roja, Rudchenko, Sergei, von Bernuth, Horst, Zhang, Shen-Ying, Puel, Anne, Jouanguy, Emmanuelle, Picard, Capucine, Garty, Ben-Zion, Camcioglu, Yildiz, Doffinger, Rainer, Kumararatne, Dinakantha, Davies, Graham, Gallin, John I., Haraguchi, Soichi, Day, Noorbibi K., Casanova, Jean-Laurent, Meffre, Eric
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666307/
https://ncbi.nlm.nih.gov/pubmed/19006693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2008.09.015
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