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Structural insights into TDP-43 in nucleic-acid binding and domain interactions
TDP-43 is a pathogenic protein: its normal function in binding to UG-rich RNA is related to cystic fibrosis, and inclusion of its C-terminal fragments in brain cells is directly linked to frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Here we report the 1.65 Å crys...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2665213/ https://ncbi.nlm.nih.gov/pubmed/19174564 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp013 |
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