G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models

Recent studies suggest that tumor-associated CD11b(+)Gr1(+) myeloid cells contribute to refractoriness to antiangiogenic therapy with an anti-VEGF-A antibody. However, the mechanisms of peripheral mobilization and tumor-homing of CD11b(+)Gr1(+) cells are unclear. Here, we show that, compared with ot...

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Bibliografiske detaljer
Main Authors: Shojaei, Farbod, Wu, Xiumin, Qu, Xueping, Kowanetz, Marcin, Yu, Lanlan, Tan, Martha, Meng, Y. Gloria, Ferrara, Napoleone
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665197/
https://ncbi.nlm.nih.gov/pubmed/19346489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902280106
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