Structural Basis of Glyphosate Resistance Resulting from the Double Mutation Thr(97) → Ile and Pro(101) → Ser in 5-Enolpyruvylshikimate-3-phosphate Synthase from Escherichia coli

The shikimate pathway enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) is the target of the broad spectrum herbicide glyphosate. The genetic engineering of EPSPS led to the introduction of glyphosate-resistant crops worldwide. The genetically engineered corn lines NK603 and GA21 carry dist...

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Detalhes bibliográficos
Main Authors: Funke, Todd, Yang, Yan, Han, Huijong, Healy-Fried, Martha, Olesen, Sanne, Becker, Andreas, Schönbrunn, Ernst
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665107/
https://ncbi.nlm.nih.gov/pubmed/19211556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809771200
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