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Expression of the P2X(7) Receptor Increases the Ca(2+) Content of the Endoplasmic Reticulum, Activates NFATc1, and Protects from Apoptosis
The P2X(7) receptor is known for the cytotoxic activity because of its ability to cause opening of non-selective pores in the plasma membrane and activate apoptotic caspases. A key factor of P2X(7)-dependent cytotoxicity is the massive intracellular Ca(2+) increase triggered by its activation. Here...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2665066/ https://ncbi.nlm.nih.gov/pubmed/19204004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805805200 |
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