p53 at the endoplasmic reticulum regulates apoptosis in a Ca(2+)-dependent manner

The tumor suppressor p53 is a key protein in preventing cell transformation and tumor progression. Activated by a variety of stimuli, p53 regulates cell-cycle arrest and apoptosis. Along with its well-documented transcriptional control over cell-death programs within the nucleus, p53 exerts crucial...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Giorgi, Carlotta, Bonora, Massimo, Sorrentino, Giovanni, Missiroli, Sonia, Poletti, Federica, Suski, Jan M., Galindo Ramirez, Fabian, Rizzuto, Rosario, Di Virgilio, Francesco, Zito, Ester, Pandolfi, Pier Paolo, Wieckowski, Mariusz R., Mammano, Fabio, Del Sal, Giannino, Pinton, Paolo
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330769/
https://ncbi.nlm.nih.gov/pubmed/25624484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410723112
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