Identification of PTEN at the ER and MAMs and its regulation of Ca(2+) signaling and apoptosis in a protein phosphatase-dependent manner

The tumor suppressor activity of PTEN (phosphatase and tensin homolog deleted on chromosome 10) is thought to be largely attributable to its lipid phosphatase activity. PTEN dephosphorylates the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate to directly antagonize the phosphoinositi...

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Detalhes bibliográficos
Main Authors: Bononi, A, Bonora, M, Marchi, S, Missiroli, S, Poletti, F, Giorgi, C, Pandolfi, P P, Pinton, P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824603/
https://ncbi.nlm.nih.gov/pubmed/23811847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.77
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