Nicotine is a Selective Pharmacological Chaperone of Acetylcholine Receptor Number and Stoichiometry. Implications for Drug Discovery

The acronym SePhaChARNS, for “selective pharmacological chaperoning of acetylcholine receptor number and stoichiometry,” is introduced. We hypothesize that SePhaChARNS underlies classical observations that chronic exposure to nicotine causes “upregulation” of nicotinic receptors (nAChRs). If the hyp...

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Autors principals: Lester, Henry A., Xiao, Cheng, Srinivasan, Rahul, Son, Cagdas D., Miwa, Julie, Pantoja, Rigo, Banghart, Matthew R., Dougherty, Dennis A., Goate, Alison M., Wang, Jen C.
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2009
Matèries:
Mini-Review
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664890/
https://ncbi.nlm.nih.gov/pubmed/19280351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-009-9090-7
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