Nicotine is a Selective Pharmacological Chaperone of Acetylcholine Receptor Number and Stoichiometry. Implications for Drug Discovery

The acronym SePhaChARNS, for “selective pharmacological chaperoning of acetylcholine receptor number and stoichiometry,” is introduced. We hypothesize that SePhaChARNS underlies classical observations that chronic exposure to nicotine causes “upregulation” of nicotinic receptors (nAChRs). If the hyp...

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Bibliografiske detaljer
Main Authors: Lester, Henry A., Xiao, Cheng, Srinivasan, Rahul, Son, Cagdas D., Miwa, Julie, Pantoja, Rigo, Banghart, Matthew R., Dougherty, Dennis A., Goate, Alison M., Wang, Jen C.
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2009
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664890/
https://ncbi.nlm.nih.gov/pubmed/19280351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-009-9090-7
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