Nicotine is a Selective Pharmacological Chaperone of Acetylcholine Receptor Number and Stoichiometry. Implications for Drug Discovery

The acronym SePhaChARNS, for “selective pharmacological chaperoning of acetylcholine receptor number and stoichiometry,” is introduced. We hypothesize that SePhaChARNS underlies classical observations that chronic exposure to nicotine causes “upregulation” of nicotinic receptors (nAChRs). If the hyp...

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Main Authors: Lester, Henry A., Xiao, Cheng, Srinivasan, Rahul, Son, Cagdas D., Miwa, Julie, Pantoja, Rigo, Banghart, Matthew R., Dougherty, Dennis A., Goate, Alison M., Wang, Jen C.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2009
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Mini-Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664890/
https://ncbi.nlm.nih.gov/pubmed/19280351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-009-9090-7
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