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Nicotine Normalizes Intracellular Subunit Stoichiometry of Nicotinic Receptors Carrying Mutations Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy

Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is linked with high penetrance to several distinct nicotinic receptor (nAChR) mutations. We studied (α4)(3)(β2)(2) versus (α4)(2)(β2)(3) subunit stoichiometry for five channel-lining M2 domain mutations: S247F, S252L, 776ins3 in α4, V287L,...

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Bibliografische gegevens
Hoofdauteurs: Son, Cagdas D., Moss, Fraser J., Cohen, Bruce N., Lester, Henry A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Pharmacology and Experimental Therapeutics 2009
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2672806/
https://ncbi.nlm.nih.gov/pubmed/19237585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.054494
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