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Nicotine Normalizes Intracellular Subunit Stoichiometry of Nicotinic Receptors Carrying Mutations Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy

Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is linked with high penetrance to several distinct nicotinic receptor (nAChR) mutations. We studied (α4)(3)(β2)(2) versus (α4)(2)(β2)(3) subunit stoichiometry for five channel-lining M2 domain mutations: S247F, S252L, 776ins3 in α4, V287L,...

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Bibliografiska uppgifter
Huvudupphovsmän: Son, Cagdas D., Moss, Fraser J., Cohen, Bruce N., Lester, Henry A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Pharmacology and Experimental Therapeutics 2009
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2672806/
https://ncbi.nlm.nih.gov/pubmed/19237585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.054494
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