Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia

CONTEXT: Pediatric acute lymphoblastic leukemia (ALL) is the prototype for a drug-responsive malignancy. Although cure rates exceed 80%, considerable unexplained interindividual variability exists in treatment response. OBJECTIVE: Using a genome-wide approach, to assess the contribution of inherited...

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Main Authors: Yang, Jun, Cheng, Cheng, Yang, Wenjian, Pei, Deqing, Cao, Xueyuan, Fan, Yiping, Pounds, Stan, Treviño, Lisa R., French, Deborah, Campana, Dario, Downing, James R., Evans, William E., Pui, Ching-Hon, Devidas, Meenakshi, Bowman, W.P., Camitta, Bruce M., Willman, Cheryl, Davies, Stella M., Borowitz, Michael J., Carroll, William L., Hunger, Stephen P., Relling, Mary V.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664534/
https://ncbi.nlm.nih.gov/pubmed/19176441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2009.7
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