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Phosphoproteomic analysis of human brain by calcium phosphate precipitation and mass spectrometry

Alzheimer’s disease (AD), the most common form of dementia, is manifested in the brain by the aggregation of amyloid plaques and neurofibrillary tangles. The tangles are primarily composed of microtubule-associated protein tau that is aberrantly hyperphosphorylated, suggesting that deregulated phosp...

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Détails bibliographiques
Auteurs principaux: Xia, Qiangwei, Cheng, Dongmei, Duong, Duc M., Gearing, Marla, Lah, James J., Levey, Allan I., Peng, Junmin
Format: Artigo
Langue:Inglês
Publié: 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663965/
https://ncbi.nlm.nih.gov/pubmed/18510355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr8000496
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