Diacylglycerol Kinase ζ Regulates Actin Cytoskeleton Reorganization through Dissociation of Rac1 from RhoGDI

Activation of Rac1 GTPase signaling is stimulated by phosphorylation and release of RhoGDI by the effector p21-activated kinase 1 (PAK1), but it is unclear what initiates this potential feed-forward mechanism for regulation of Rac activity. Phosphatidic acid (PA), which is produced from the lipid se...

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Bibliographic Details
Main Authors: Abramovici, Hanan, Mojtabaie, Parmiss, Parks, Robin J., Zhong, Xiao-Ping, Koretzky, Gary A., Topham, Matthew K., Gee, Stephen H.
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2009
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663923/
https://ncbi.nlm.nih.gov/pubmed/19211846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-12-1248
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