RAGE-Induced Cytosolic ROS Promote Mitochondrial Superoxide Generation in Diabetes

Damaged mitochondria generate an excess of superoxide, which may mediate tissue injury in diabetes. We hypothesized that in diabetic nephropathy, advanced glycation end-products (AGEs) lead to increases in cytosolic reactive oxygen species (ROS), which facilitate the production of mitochondrial supe...

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Detalhes bibliográficos
Main Authors: Coughlan, Melinda T., Thorburn, David R., Penfold, Sally A., Laskowski, Adrienne, Harcourt, Brooke E., Sourris, Karly C., Tan, Adeline L.Y., Fukami, Kei, Thallas-Bonke, Vicki, Nawroth, Peter P., Brownlee, Michael, Bierhaus, Angelika, Cooper, Mark E., Forbes, Josephine M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2009
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663823/
https://ncbi.nlm.nih.gov/pubmed/19158353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2008050514
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