Ramipril inhibits AGE-RAGE-induced matrix metalloproteinase-2 activation in experimental diabetic nephropathy

BACKGROUND: Advanced glycation end products (AGE)-receptor for AGE (RAGE) axis and renin-angiotensin system (RAS) play a role in diabetic nephropathy (DN). Matrix metalloproteinase-2 (MMP-2) activation also contributes to DN. However, the pathological interaction among AGE-RAGE, RAS and MMP-2 in DN...

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Detalhes bibliográficos
Main Authors: Fukami, Kei, Yamagishi, Sho-ichi, Coughlan, Melinda T, Harcourt, Brooke E, Kantharidis, Phillip, Thallas-Bonke, Vicki, Okuda, Seiya, Cooper, Mark E, Forbes, Josephine M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138378/
https://ncbi.nlm.nih.gov/pubmed/25143788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1758-5996-6-86
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