DNA Ligase I Deficiency Leads to Replication-Dependent DNA Damage and Impacts Cell Morphology without Blocking Cell Cycle Progression

46BR.1G1 cells derive from a patient with a genetic syndrome characterized by drastically reduced replicative DNA ligase I (LigI) activity and delayed joining of Okazaki fragments. Here we show that the replication defect in 46BR.1G1 cells results in the accumulation of both single-stranded and doub...

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Autori principali: Soza, Samuela, Leva, Valentina, Vago, Riccardo, Ferrari, Giovanni, Mazzini, Giuliano, Biamonti, Giuseppe, Montecucco, Alessandra
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2009
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663296/
https://ncbi.nlm.nih.gov/pubmed/19223467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01730-08
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