DNA ligase I is recruited to sites of DNA replication by an interaction with proliferating cell nuclear antigen: identification of a common targeting mechanism for the assembly of replication factories.

In mammalian cells, DNA replication occurs at discrete nuclear sites termed replication factories. Here we demonstrate that DNA ligase I and the large subunit of replication factor C (RF-C p140) have a homologous sequence of approximately 20 amino acids at their N-termini that functions as a replica...

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Detalhes bibliográficos
Main Authors: Montecucco, A, Rossi, R, Levin, D S, Gary, R, Park, M S, Motycka, T A, Ciarrocchi, G, Villa, A, Biamonti, G, Tomkinson, A E
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170714/
https://ncbi.nlm.nih.gov/pubmed/9649448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.13.3786
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