The N-terminal domain of human DNA ligase I contains the nuclear localization signal and directs the enzyme to sites of DNA replication.

DNA replication in mammalian cells occurs in discrete nuclear foci called 'replication factories'. Here we show that DNA ligase I, the main DNA ligase activity in proliferating cells, associates with the factories during S phase but displays a diffuse nucleoplasmic distribution in non-S phase nuclei...

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Dettagli Bibliografici

Pubblicato in:	EMBO J
Autori principali:	Montecucco, A, Savini, E, Weighardt, F, Rossi, R, Ciarrocchi, G, Villa, A, Biamonti, G
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394647/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7489727/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1995.tb00222.x
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