Reducing the Risk of Adeno-Associated Virus (AAV) Vector Mobilization with AAV Type 5 Vectors

Current adeno-associated virus (AAV) gene therapy vectors package a transgene flanked by the terminal repeats (TRs) of AAV type 2 (AAV2). Although these vectors are replication deficient, wild-type (wt) AAV2 prevalent in the human population could lead to replication and packaging of a type 2 TR (TR...

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Détails bibliographiques
Auteurs principaux: Hewitt, F. Curtis, Li, Chengwen, Gray, Steven J., Cockrell, Shelley, Washburn, Michael, Samulski, R. Jude
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2009
Sujets:
Gene Delivery
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663261/
https://ncbi.nlm.nih.gov/pubmed/19211760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02466-08
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