Phosphorylation of the Human Papillomavirus Type 16 E1^E4 Protein at T57 by ERK Triggers a Structural Change That Enhances Keratin Binding and Protein Stability

The E1^E4 protein of human papillomavirus type 16 (HPV16) causes cytokeratin reorganization in the middle and upper epithelial layers and is thought to contribute to multiple facets of the virus life cycle. Although little is known as to how HPV16 E1^E4 (16E1^E4) functions are controlled following t...

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Main Authors: Wang, Qian, Kennedy, Alan, Das, Papia, McIntosh, Pauline B., Howell, Steven A., Isaacson, Erin R., Hinz, Steven A., Davy, Clare, Doorbar, John
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2009
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663250/
https://ncbi.nlm.nih.gov/pubmed/19211765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02063-08
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