Structural Analysis Reveals an Amyloid Form of the Human Papillomavirus Type 16 E1(∧)E4 Protein and Provides a Molecular Basis for Its Accumulation

The abundant human papillomavirus (HPV) type 16 E4 protein exists as two distinct structural forms in differentiating epithelial cells. Monomeric full-length 16E1(∧)E4 contains a limited tertiary fold constrained by the N and C termini. N-terminal deletions facilitate the assembly of E1(∧)E4 into am...

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Detalhes bibliográficos
Main Authors: McIntosh, Pauline B., Martin, Stephen R., Jackson, Deborah J., Khan, Jameela, Isaacson, Erin R., Calder, Lesley, Raj, Kenneth, Griffin, Heather M., Wang, Qian, Laskey, Peter, Eccleston, John F., Doorbar, John
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519553/
https://ncbi.nlm.nih.gov/pubmed/18562538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00509-08
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