Titin and Diaphragm Dysfunction in Chronic Obstructive Pulmonary Disease

Rationale: Recently, we have shown that Ca(2+)-activated force generation in diaphragm single fibers is impaired in patients with mild to moderate chronic obstructive pulmonary disease (COPD). For optimal active-force generation, the passive elasticity provided by titin is indispensable. Objectives:...

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Detalhes bibliográficos
Main Authors: Ottenheijm, Coen A. C., Heunks, Leo M. A., Hafmans, Theo, van der Ven, Peter F. M., Benoist, Caroline, Zhou, Honghui, Labeit, Siegfried, Granzier, Henk L., Dekhuijzen, P. N. Richard
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2006
Assuntos:
C. Chronic Obstructive Pulmonary Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662936/
https://ncbi.nlm.nih.gov/pubmed/16339921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200507-1056OC
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